White PaperMaterials
Mixing Technologies in the Pharmaceutical and Medical Industries
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This white paper presents an overview of mixing technologies implemented across many of today’s highly competitive pharmaceutical and medical industries, as well as new equipment designs that are increasingly being recognized as potential solutions to prevailing mixing challenges. Mixing applications falling within the broad spectrum of mass-produced pharmaceutical goods and medical devices are too many and complex to discuss in detail hence this paper will touch on a few general classifications as well as a few examples within that mixing category.
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Overview
The white paper titled "Mixing Technologies in the Pharmaceutical and Medical Industries" by Charles Ross & Son Company provides a comprehensive overview of the critical role mixing technologies play in the production of pharmaceuticals and medical devices. It emphasizes that mixing is not merely about combining ingredients; it serves multiple purposes, including preparing emulsions, reducing particle sizes, facilitating chemical reactions, and ensuring product stability.
The paper discusses the complexity of mixing processes in the healthcare sector, which adhere to strict regulations for accuracy, consistency, and cleanliness. It highlights that different mixing technologies are required for various applications, as no single design can meet all needs. The document categorizes mixers based on phase and viscosity, detailing the capabilities of various types, such as high shear mixers, multi-shaft mixers, and kneader extruders, each suited for specific viscosity ranges.
A key focus is on the SLIM (Solids/Liquid Injection Manifold) technology, which enhances the efficiency of powder induction into liquid phases. This system allows for the immediate dispersion of hard-to-mix powders, significantly reducing processing times and improving throughput. The paper provides examples of successful implementations, such as the use of SLIM in producing glucosamine and chondroitin supplements, which increased batch processing efficiency by 275%.
The importance of continuous updates on mixer systems and designs is stressed, as advancements can lead to improved efficiencies and cost-effectiveness. The paper concludes by discussing the two approaches to selecting mixing systems: one based on mechanical specifications and the other on process specifications. The ideal selection process combines both approaches to ensure optimal mixer performance tailored to specific production needs.
Overall, the white paper serves as a valuable resource for R&D scientists and process engineers, highlighting the significance of proper mixer selection in achieving high-quality pharmaceutical products.