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White Papers
Medical

Passivation, Pickling or Electropolishing: Which Metal Finishing Process Is Right for Your Parts?

In our latest whitepaper, we explore the differences and benefits of three common metal finishing techniques. From microcracks and microburrs...

White Papers
Medical

Your Solution to 7 Metal Surface Problems

Electropolishing is the preferred finishing method for critical metal parts across industries.

Briefs
Medical

Method and Apparatus for Performance Optimization Through Physical Perturbation of Task Elements

NASA’s Langley Research Center has developed ZONE, an innovative method for improving athletes’ responses to stress, anxiety, and loss of...

Briefs
Medical

Portable Medical Diagnosis Instrument

NASA has developed a novel technology strategy called “The NASA Analyzer” that would provide comprehensive in-flight medical diagnostic capability in a compact, handheld device for human deep-space...

Briefs
Medical

Device and Method for Healing Wounds

This technology is a device that uses electrical activity to facilitate the wound healing process while protecting the wound. The bandage is made of an electroactive material (see figure) that is...

Briefs
Medical

Fluid Preservation System (FPS)

Biological samples contain labile molecules that deteriorate rapidly ex-vivo. Terrestrially, biological samples are preserved either by freezing them (–80 °C) or by including preservation chemicals. While chemical preservation may be ideal for certain molecules, their functionality is selective and can, while...

Briefs
Medical

Intranasal Scopolamine — INSCOP

Space motion sickness (SMS) commonly experienced by astronauts during a space mission often requires treatment with medication. However, exposure to a microgravity environment results in a myriad of physiological changes that alter bioavailability. In particular, studies indicate that the bioavailability of oral...

Briefs
Medical

Gene Expression Signatures for Colon Carcinogenesis and Radiation-Induced Cellular Transformation

Monitoring colon health and transformation into a diseased tissue, including inflammation and cancer, is difficult using conventional techniques, as individuals are required to undergo invasive procedures. However, by using exfoliated cells, it is...

Briefs
Medical

Method and Apparatus for Automated Isolation of Nucleic Acids from Small Cell Samples

RNA isolation is a ubiquitous need, driven by current emphasis on micro-arrays and miniaturization. With commercial systems requiring 100,000 to 1,000,000 cells for successful isolation, there is a growing need for a small-footprint, easy-to-use device that can...

Briefs
Medical

A Novel Protocol for Decoating and Permeabilizing Bacterial Spores for Epifluorescent Microscopy

Based on previously reported procedures for permeabilizing vegetative bacterial cells, and numerous trial-and-error attempts with bacterial endospores, a protocol was developed for effectively permeabilizing bacterial spores, which facilitated the...

Briefs
Medical

On-Command Force and Torque Impeding Devices (OC-FTID) Using ERF

Various machines have been developed to address the need for countermeasures of bone and muscle deterioration when humans operate over extended time in space. Even though these...

Briefs
Medical

FRET-Aptamer Assays for Bone Marker Assessment, C-Telopeptide, Creatinine, and Vitamin D

Astronauts lose 1.0 to 1.5% of their bone mass per month on long-duration spaceflights. NASA wishes to monitor the bone loss onboard spacecraft to develop nutritional and exercise countermeasures, and make adjustments during long space missions. On Earth,...

Briefs
Medical

Medicine Delivery Device With Integrated Sterilization and Detection

Sterile delivery devices can be created by integrating a medicine delivery instrument with surfaces that are coated with germicidal and anti-fouling material. This requires...

Briefs
Medical

Improved Cell Culture Method for Growing Contracting Skeletal Muscle Models

An improved method for culturing immature muscle cells (myoblasts) into a mature skeletal muscle overcomes some of the notable limitations of prior culture methods....

Briefs
Medical

Extreme Ionizing-Radiation-Resistant Bacterium

There is a growing concern that desiccation and extreme radiation-resistant, non-spore-forming microorganisms associated with spacecraft surfaces can withstand space environmental conditions and subsequent proliferation on another solar body. Such forward contamination would jeopardize future life...

Briefs
Software

Developing Physiologic Models for Emergency Medical Procedures Under Microgravity

Several technological enhancements have been made to METI’s commercial Emergency Care Simulator (ECS) with regard to how microgravity affects human physiology. The ECS uses both a software only lung simulation, and an integrated mannequin lung that uses a...

Briefs
Test & Measurement

Beat-to-Beat Blood Pressure Monitor

This device provides non-invasive beat-to-beat blood pressure measurements and can be worn over the upper arm for prolonged durations. Phase and waveform analyses are performed on filtered proximal and distal photoplethysmographic (PPG) waveforms obtained from the brachial artery. The phase analysis is used...

Briefs
Medical

Improving Balance Function Using Low Levels of Electrical Stimulation of the Balance Organs

Crewmembers returning from long duration space flight face significant challenges due to the microgravity induced inappropriate adaptations in balance/sensorimotor function. The Neuroscience Laboratory at JSC is developing a method based on stochastic...

Briefs
Medical

Hands-Free Transcranial Color Doppler Probe

Current transcranial color Doppler (TCD) transducer probes are bulky and difficult to move in tiny increments to search and optimize TCD signals. This invention provides miniature motions of a TCD transducer probe to optimize TCD signals.

Briefs
Medical

PMA-Linked Fluorescence for Rapid Detection of Viable Bacterial Endospores

The most common approach for assessing the abundance of viable bacterial endospores is the culture-based plating method. However, culture-based approaches are heavily biased and oftentimes incompatible with upstream sample processing strategies, which make viable...

Briefs
Medical

Experimental Modeling of Sterilization Effects for Atmospheric Entry Heating on Microorganisms

The objective of this research was to design, build, and test an experimental apparatus for studying the parameters of atmospheric entry heating,...

Briefs
Medical

Loading, Release, Biodegradation, and Biocompatibility of a Nanovector Delivery System

A nanovector multistage system has been created to overcome or bypass sequential barriers within the human body, in order to deliver a therapeutic or...

Briefs
Medical

Improved Whole-Blood-Staining Device

Dramatic improvements have been made in NASA’s Whole Blood Staining Device (WBSD) since it was last described in “Whole-Blood- Staining Device,” (MSC-22614) NASA Tech Briefs, Vol. 23, No. 10...

Briefs
Medical

Handheld Universal Diagnostic Sensor

The rHEALTH technology is designed to shrink an entire hospital testing laboratory onto a handheld device. A physician or healthcare provider performs the test by collecting a fingerstick of blood from a...

Briefs
Medical

Radiation Protection Using Single-Wall Carbon Nanotube Derivatives

This invention is a means of radiation protection, or cellular oxidative stress mitigation, via a sequence of quenching radical species using nano-engineered scaffolds, specifically single-wall carbon nanotubes (SWNTs) and their derivatives. The material can be used as a means of...

Briefs
Medical

PMA-PhyloChip DNA Microarray To Elucidate Viable Microbial Community Structure

Since the Viking missions in the mid- 1970s, traditional culture-based methods have been used for microbial enumeration by various NASA programs. Viable microbes are of particular concern for spacecraft cleanliness, for forward contamination of extraterrestrial bodies...

Briefs
Medical

Improved Devices for Collecting Sweat for Chemical Analysis

Improved devices have been proposed for collecting sweat for biochemical analysis — especially for determination of the concentration of Ca2+ ions in sweat as a measure of loss of Ca from bones. Unlike commercially available sweat-collection patches used previously in...

Briefs
Medical

Cytometer on a Chip

A cytometer now under development exploits spatial sorting of sampled cells on a microarray chip followed by use of grating-coupled surface-plasmon-resonance imaging (GCSPRI) to detect the sorted cells. This cytometer on a chip is a prototype of contemplated future miniature cytometers that would be suitable for rapidly...

Briefs
Medical

Tissue Photolithography

Tissue lithography will enable physicians and researchers to obtain macromolecules with high purity (>90 percent) from desired cells in conventionally processed, clinical tissues by simply annotating the desired cells on a computer screen. After identifying the desired cells, a suitable lithography mask will be generated...